UCLA scientists have identified how immune cells detect and respond to cancer cells, leading to better personalized immunotherapies for patients who do not respond to treatment. Checkpoint inhibitors improve T cells' ability to recognize and attack cancer cells, and the study showed that when immunotherapy is effective, it directs a diverse repertoire of T cells against a small group of selected mutations in a tumor. The researchers adapted advanced gene-editing technology to make unprecedented observations about immune responses in patients with metastatic melanoma receiving anti-PD-1 "checkpoint inhibitor" immunotherapy.

HIV, the virus that causes AIDS, is a master of disguise. It can change its outer coat of proteins frequently, making it hard for the immune system to recognise and destroy it. HIV targets Helper T cells, which act as the air traffic controllers of the immune system, coordinating the efforts of other immune cells. If Helper T cells disappear, the whole immune system would have trouble fighting not just HIV but many other illnesses as well. Boosting the immune system against HIV requires getting the Helper T cells back in control. Learning about the immune system and how it works can help you understand how HIV affects the body and how to boost your immune system against it. By exploring this topic through reading, reflection, writing and self-directed projects, you can gain a deeper understanding of the immune system and how to protect yourself from harmful intruders like viruses and bacteria.

As we grow older, our bodies undergo many changes, including changes in our metabolism. Metabolism refers to the chemical processes that occur in our bodies to maintain life. These processes are essential for providing energy, building and repairing tissues, and eliminating waste products. As we age, our metabolic pathways can become altered, leading to various age-related diseases and conditions. One example of a metabolic pathway that is affected by aging is the mitochondrial electron transport chain (ETC). The ETC is responsible for producing ATP, the primary source of energy for our cells. As we age, the function of the ETC can become impaired, leading to a decrease in ATP production and an increase in oxidative stress. This can contribute to age-related diseases such as Alzheimer's disease, Parkinson's disease, and diabetes. Another example is the mTOR (mechanistic target of rapamycin) pathway, which regulates cellular growth and metabolism. Studies have shown that inhibiting the mTOR pathway can increase lifespan in various model organisms, including mice. This has led to increased interest in developing drugs that target this pathway as a potential anti-aging strategy. One of the leading academics in this field is Dr. David Sinclair, a Professor of Genetics at Harvard Medical School. Dr. Sinclair's research has focused on the role of metabolism in aging and age-related diseases, and he has made significant contributions to the field. For example, his research has shown that supplementing with NAD+, a molecule involved in energy metabolism, can improve various aspects of aging in mice. Another leading academic in this field is Dr. Valter Longo, a Professor of Gerontology and Biological Science at the University of Southern California. Dr. Longo's research has focused on the role of fasting and caloric restriction in aging and age-related diseases. His work has shown that periodic fasting can have a range of health benefits, including improving insulin sensitivity and reducing inflammation. In conclusion, the study of metabolic pathways in aging is a fascinating and rapidly growing field. By understanding the complex interplay between metabolism and aging, we can better understand the underlying causes of age-related diseases and conditions. Students who are interested in this topic can continue to explore it through reading and research, or by pursuing their own experiments and projects. With the right tools and resources, they can make meaningful contributions to this exciting field and help improve our understanding of aging and metabolic pathways.

A groundbreaking study by the University of Oxford as part of the UK's 100,000 Genomes Project has defined five new subgroups of chronic lymphocytic leukaemia (CLL) and linked these to clinical outcomes, paving the way for more personalized patient care. This is the first study to analyze all the relevant changes in DNA across the entire cancer genome!

Childhood cancer is a devastating disease that affects thousands of children every year. However, as cancer is more likely to occur in adults rather than children, research on childhood cancer is often underfunded, leading to fewer treatment options and lower survival rates. One of the biggest challenges in treating childhood cancer is the risk of long-term side effects from chemotherapy and radiation. These treatments can cause developmental delays, learning disabilities, and even secondary cancers later in life. As a result, new treatment strategies are being developed to minimize these risks. One of the most promising new approaches is immunotherapy, a type of treatment that harnesses the power of the immune system to attack cancer cells. CAR T-cell therapy, in which T-cells are genetically engineered to recognize and attack cancer cells, has shown particularly promising results in clinical trials. Another challenge in treating childhood cancer is the lack of targeted therapies. Unlike adult cancers, childhood cancers often have no known driver mutations that can be targeted with precision medicine. Researchers are working to identify new drug targets and develop new treatments that can attack cancer cells while sparing healthy cells. Dr. Kimberly Stegmaier, an oncologist and researcher at the Dana-Farber Cancer Institute, is one of the leading experts in childhood cancer research. She and her team are working to identify new drug targets and develop targeted therapies for childhood cancers. They are also studying the genetic and molecular characteristics of childhood cancers to better understand how they develop and how they can be treated. In conclusion, childhood cancer presents unique challenges that require innovative solutions. While underfunded research and the lack of targeted therapies have made progress difficult, recent developments in immunotherapy, such as CAR T-cell therapy, show promising results. As we continue to fight for a cure, let us also remember the children and families affected by this disease and strive to support them in any way we can.

Scientists have developed a groundbreaking treatment for blood cancer using off-the-shelf T-cells. The CALM clinical trial evaluated the potential of UCART19, an "off-the-shelf" CAR-T cell product, against adult patients with B-ALL. The results were recently published in The Lancet Haematology and Cancer Research Communications, showing that 48% of treated patients achieved complete remission lasting an average of 7.4 months. This new approach offers a more efficient and effective alternative to traditional CAR-T cell therapy, providing hope for patients with relapsed or treatment-resistant blood cancers.

Medical research is a fascinating field of study that explores the complexities of the human body and its many diseases. It's an exciting area of research that is constantly evolving, with new discoveries and innovations being made every day. One of the most appealing aspects of medical research is the potential to make a real difference in people's lives. Researchers in this field are at the forefront of developing new treatments and therapies for a wide range of illnesses, from cancer to Alzheimer's disease. One example of groundbreaking research in this field is the development of immunotherapy, a treatment that harnesses the power of the immune system to fight cancer. This innovative approach has already helped to save countless lives and is just one example of the many exciting breakthroughs being made in medical research. At the undergraduate level, students can expect to take a variety of modules that cover topics such as genetics, molecular biology, and epidemiology. These modules provide a solid foundation in the basic principles of medical research and prepare students for further specialisation in areas such as cancer research or infectious diseases. Potential future jobs and roles in medical research include positions as research scientists, clinical trial coordinators, and medical writers. There are also many opportunities to work in public health or in the pharmaceutical industry, with notable employers including the National Institutes of Health, Pfizer, and GlaxoSmithKline. To succeed in this field of study, students should have a strong interest in science and a passion for helping others. They should also possess excellent analytical and critical thinking skills, as well as the ability to work independently and as part of a team. Overall, the study of medical research is an exciting and rewarding field that offers endless possibilities for those who are passionate about making a difference in the world of healthcare.

Organ transplants are a life-saving medical breakthrough that have revolutionized the field of medicine. Kidneys are essential organs that filter waste material from the blood and process it into urine. A typical dialysis patient has a poorer life expectancy than many cancers. Removing one kidney should not affect someone's lifespan or quality of life. A kidney from a living donor in general will have a much better quality because it comes from a healthy and tested person. Kidneys are expected to survive up to twice as long on average in the recipient. Currently, it's not allowed to donate a kidney under any form of payment. However, incentivizing people to donate more is actually a way to starve black markets. It's not to recreate them, it's to undermine them. If you reward a person amply for the sacrifice they've made, something they go into with their eyes open and well informed, that's not exploitation. Organ donation is an incredible gift that can save someone's life so palpably, and everyone should consider donating.

The history of blood transfusions is a fascinating and important academic concept that can benefit high school students in many ways. Learning about the discovery of blood types and the science behind antibodies and antigens can help students understand the human body and the immune system. Additionally, the practical applications of this knowledge are vast, as blood transfusions have saved countless lives throughout history. By exploring this topic through reading, reflection, and self-directed projects, students can gain a deeper understanding of medical advancements and the impact they have on society. This can also inspire students to pursue careers in medical fields, where they can make a difference in the lives of others. Overall, the history of blood transfusions is a compelling and relatable topic that can encourage students to explore academic concepts independently and engage with the world around them.

Get ready to revolutionize the way we treat cancer and age-related diseases! A new company, GlioQuell, co-founded by Dr. Kambiz Alavian from the Department of Brain Sciences, is developing a cutting-edge approach to target the powerhouses of cancer cells - the mitochondria. By reducing the efficiency of these structures, GlioQuell aims to turn off the cancer cells' energy supply and treat one of the most aggressive forms of cancer - glioblastoma.

Genome-edited CAR T-cells treated a young patient's incurable T-cell leukaemia, leading to complete remission after just 28 days. Designed and developed by researchers at UCL and GOSH, the treatment represents a cutting-edge approach that paves the way for other new treatments and ultimately better futures for sick children.

Are you interested in pursuing a career that enables you to make a difference in people's lives while helping them? The field of surgery may be the ideal fit for you! Surgeons are highly skilled medical professionals responsible for performing operations to cure and treat a wide range of diseases and injuries. Let's delve deeper into what it takes to build a career in surgery. As a surgeon, your primary responsibility is to perform surgeries and other medical procedures to diagnose and treat various ailments and conditions. You'll be working with patients of all ages, from infants to the elderly, in several specializations, including neurosurgery, orthopedic surgery, plastic surgery, cardiothoracic surgery, and more. One of the most compelling aspects of a career in surgery is the chance to have a significant and long-lasting impact on people's lives. For example, as a neurosurgeon, you can perform life-saving brain surgeries, while as a plastic surgeon, you can help boost someone's confidence and self-esteem by fixing their physical defects. To become a surgeon, you'll need to earn a medical degree, complete a residency program, and get a state license. The entire process of education and training may take up to 14 years, including undergraduate studies in biology, chemistry, or pre-med. Excellent manual dexterity, communication and interpersonal skills, and the ability to work under pressure are essential qualities for success in this field. Attention to detail, critical thinking, and problem-solving skills are equally vital. The job prospects and long-term outlook for surgeons are favorable, with an expected job growth of 4% over the next decade. Surgeons are in high demand worldwide, with hospitals, private clinics, research institutions, and government agencies being some of the potential employers. Numerous top-notch organizations are looking for talented surgeons to join their teams, including the Mayo Clinic, Johns Hopkins Hospital, Cleveland Clinic in the USA, the Royal London Hospital in the UK, and St. Vincent's Hospital in Australia. In conclusion, if you're looking for a fulfilling and exciting career that allows you to make a difference in people's lives while working in a challenging and rewarding field, surgery may be the perfect career path for you. Take the time to explore this field further and see if it's the right choice for you!

Vaccines are likely the most important public health intervention of the last 100 years, having saved over a billion lives. They have led to a massive reduction in child mortality in sub-Saharan Africa and can even prevent cancer. A world without vaccines would be unimaginable, with outbreaks of disease regularly all over the world. Vaccines are the only public health intervention that can bring equality, as they protect not only oneself but also one's family and community. While anti-vaccination fears have been around for over a century, it's important to engage with people where they are and understand their context, concerns, and experiences with health and vaccines. Taking a vaccine is not just a personal choice, but a moral choice that affects other people. Vaccines are fundamental to the privileges we have in the modern world and make it a safe place for most of us to be.

Are you someone who loves to take care of their skin and is fascinated by the science of it all? Do you have an eye for detail and a passion for helping others look and feel their best? If so, then a career in dermatology might be the perfect fit for you! Dermatology is a branch of medicine that focuses on the diagnosis and treatment of skin, hair, and nail conditions. It's a field that's constantly evolving, with new research and technology being developed all the time. As a dermatologist, you'll have the opportunity to work with patients of all ages, from newborns to the elderly, and help them with a wide range of skin issues. One of the most appealing aspects of a career in dermatology is the variety of conditions you'll encounter. From acne and eczema to skin cancer and psoriasis, no two cases are the same. You'll have the chance to use your expertise to diagnose and treat these conditions, as well as perform cosmetic procedures such as Botox injections and laser hair removal. To become a dermatologist, you'll need to complete extensive education and training. This typically includes a four-year undergraduate degree in a science-related field such as biology or chemistry, followed by four years of medical school. After that, you'll need to complete a residency program in dermatology, which can take up to four years. In addition to a strong academic background, there are certain personal attributes that can be helpful in a career in dermatology. These include excellent communication skills, a compassionate nature, and a strong attention to detail. You'll also need to be comfortable working with patients of all ages and backgrounds, and be able to handle the emotional aspects of the job. The job prospects for dermatologists are excellent, with a strong demand for their services in both the public and private sectors. Some notable potential employers include hospitals, clinics, and private practices. You may also have the opportunity to work in research or academia, helping to develop new treatments and technologies for skin conditions. So if you have a passion for skin care and a desire to make a difference in people's lives, a career in dermatology might be the perfect choice for you. With hard work and dedication, you could be on your way to a fulfilling and rewarding career in this exciting field.

Do you have a passion for helping children? Do you want to make a difference in their lives? If so, then a career as a Pediatrician may be perfect for you! Pediatricians are medical doctors who specialize in the care of children, from newborns to teenagers. They play a crucial role in ensuring that children grow up healthy and strong. As a Pediatrician, you will be responsible for diagnosing and treating a wide range of illnesses and injuries that affect children. You will also provide preventive care, such as vaccinations, and help parents and caregivers to understand how to keep their children healthy. One of the most appealing aspects of this career is the opportunity to make a real difference in the lives of children. You may be the one to identify a serious illness early on, saving a child's life. Or you may be the one to help a child overcome a chronic condition, allowing them to thrive and reach their full potential. Pediatricians can specialize in a variety of areas, such as neonatology, cardiology, or oncology. This allows you to focus on the specific needs of your patients and become an expert in your field. To become a Pediatrician, you will need to complete a Bachelor's degree in a relevant field, such as Biology or Chemistry, followed by four years of medical school. After that, you will need to complete a residency program in Pediatrics, which typically lasts three years. In addition to the required education and training, there are certain personal attributes that can be helpful in this career. These include empathy, patience, and excellent communication skills. Job prospects for Pediatricians are excellent, with a projected growth rate of 14% over the next decade. There are a wide range of potential employers, including hospitals, private practices, and government agencies. Some notable employers include Children's Hospital of Philadelphia, Boston Children's Hospital, and St. Jude Children's Research Hospital. In conclusion, a career as a Pediatrician can be incredibly rewarding, both personally and professionally. If you have a passion for helping children and want to make a difference in the world, then this may be the perfect career for you!

Frances Oldham Kelsey was a scientist who saved thousands of lives by rejecting an application to sell a drug called thalidomide. The drug was widely used in dozens of countries to treat insomnia, workplace stress, and nausea in pregnant women. However, Kelsey found the data on thalidomide's absorption and toxicity inadequate and rejected the application. Her earlier animal-based research demonstrated that drugs could pass from mother to fetus through the placenta, and she believed that thalidomide could cause harm to fetuses. Her decision to reject the application and ask for better evidence saved countless babies from severe birth defects caused by thalidomide. Kelsey's legacy endures as she prioritized facts over opinions and patience over shortcuts, making evidence-based medicine the foundation of reforms that continue to protect people today. By learning about Kelsey's story, students can understand the importance of evidence-based research and the impact of their decisions in science and medicine.

Genetic sequencing has revolutionized healthcare but the genomic gap, where over 86% of data is from white Europeans, is exacerbating healthcare inequalities. Discover how this gap leads to adverse drug reactions and inaccurate genetic tests for ethnic minority groups. Explore the urgent need for reinvestment to narrow the gap and provide accurate genomic information for all.

The eradication of smallpox is one of the most significant events of the 20th century. It is up there with the moon landing. This achievement was made possible by the development of vaccines and the efforts of health workers worldwide. Learning about the history of smallpox and vaccination is not only intellectually stimulating but also practically relevant, particularly in the context of the current COVID-19 pandemic. By understanding the strategies used to eradicate smallpox, such as tracking, testing, and isolating, we can gain insights into how to keep on top of COVID-19. Moreover, the successful eradication of smallpox gives us hope that we can eradicate other human diseases if we work together. As students, exploring academic topics through reading, reflection, writing, and self-directed projects can help us gain a deeper understanding of the world around us and inspire us to take action to make a positive impact.

Did you know that selecting the embryo with the lowest risk for a given disease can cut the risk for that disease by almost half? This is particularly true for disorders such as schizophrenia and Crohn’s disease. However, the selection process may not lead to significant improvements in non-disease traits such as intelligence. Moreover, the use of preimplantation genetic screening (PES) raises concerns about psychological well-being, social values, and ethics. Learn more about the potential benefits and risks of PES, and how it may impact our society and individuality.

Have you ever considered a career in Oncology? As an oncologist, you would be at the forefront of cancer care, helping patients navigate through one of the most challenging times of their lives. Not only would you be making a significant impact on the lives of those affected by cancer, but you would also be part of a field that is constantly evolving and advancing. As an oncologist, you would work with a team of healthcare professionals to diagnose and treat cancer patients. You would be responsible for developing treatment plans, monitoring patients' progress, and providing emotional support to patients and their families. Oncologists also play a vital role in cancer research, helping to develop new treatments and therapies. There are several specializations within the field of oncology, including medical oncology, radiation oncology, and surgical oncology. Medical oncologists focus on using chemotherapy and other medications to treat cancer, while radiation oncologists use radiation therapy to destroy cancer cells. Surgical oncologists, on the other hand, perform surgeries to remove cancerous tumors. To become an oncologist, you will need to complete a medical degree, followed by a residency in oncology. Popular undergraduate programs for aspiring oncologists include biology, chemistry, and pre-med. In addition to formal education, oncologists must possess excellent communication and interpersonal skills, as well as a strong desire to help others. Job prospects for oncologists are excellent, with a growing demand for cancer care worldwide. There are many potential employers in both the public and private sectors, including hospitals, research institutions, and pharmaceutical companies. Notable employers include Memorial Sloan Kettering Cancer Center, MD Anderson Cancer Center, and the National Cancer Institute. In conclusion, a career in oncology is both challenging and rewarding. By pursuing this career, you would be making a significant impact on the lives of cancer patients and their families, while also contributing to the advancement of cancer research and treatment. So if you have a passion for helping others and a desire to make a difference in the world, consider a career in oncology.