Are you curious about the tiny viruses that inhabit your body? MIT Technology Review's biotech newsletter, The Checkup, explores the world of bacteriophages, or "phages" for short. These microscopic viruses have the potential to treat bacterial infections, but they've been largely abandoned in favor of antibiotics. With antimicrobial resistance on the rise, interest in phage therapy is making a comeback. Learn about the diversity and specificity of phages, and how they could be engineered to target specific bacteria. Discover the potential of phage therapy and the challenges that need to be overcome in this fascinating article.

DNA is a molecule that holds the secrets of life within its code, and it's waiting for you to explore it! This amazing molecule determines our traits, from our physical appearance to our personalities, and it can also tell us about our ancestry, our risk of diseases, and much more. Leading academics in the field of genetics, such as James Watson and Francis Crick, made major contributions to our understanding of DNA by discovering its structure and how it stores and transfers genetic information. Watson and Crick's discovery of the double helix structure of DNA was a major turning point in the field of genetics and opened up new avenues for scientific research. In the early 1990s, the Human Genome Project was launched to map all of the genes in human DNA. This project was a huge success and has had a profound impact on the field of genetics. It allowed scientists to identify specific genes that are associated with different diseases, such as cancer, and has paved the way for new treatments and cures. One of the most fascinating things about DNA is that every person's DNA is 99.9% identical to every other person's DNA. It's the remaining 0.1% that makes each of us unique! Our DNA also contains fascinating stories about our ancestors and their migrations. For example, DNA testing can tell us where our ancestors came from and how they migrated across the world. This is known as genetic genealogy, and it's an exciting field that combines genetics and history. Another fascinating aspect of DNA is its role in evolution. Charles Darwin's theory of evolution by natural selection states that species change over time through the process of natural selection. This process occurs because certain traits that provide an advantage in survival and reproduction become more common in a population over time. DNA mutations can lead to changes in traits, and over many generations, these changes can accumulate and result in new species. By exploring the world of DNA, you will not only deepen your understanding of genetics and biology, but also gain a new appreciation for the complexities and wonders of life. So go ahead, unlock the secrets of life with the power of DNA!

Can blood rejuvenation really extend human lifespan by 10 healthy years? Silicon Valley entrepreneurs invest millions into life extension projects. But is it ethical? Read on to explore the scientific and ethical debates surrounding lifespan extension technologies.

In just a few thousand years, northern Europeans evolved to digest milk, a feat that was once impossible for adult humans. Scientists now believe that exceptional stressors like famines and pathogens may have driven this genetic change, making the ability to digest milk extra valuable. This study, published in Nature and led by experts from the University of Bristol and University College London, sheds light on the evolution of lactose tolerance and rewrites the textbooks on why drinking milk was an advantage.

Discover how human evolution has led to unique diseases like knee osteoarthritis, affecting millions worldwide. Professor Terence D. Capellini shares genetic research on the link between bipedalism and knee osteoarthritis, and how identifying high-risk patients at an early age can inform future therapies. Explore the Developmental and Evolutionary Genetics Lab's work and hypotheses published in his 2020 paper "Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk." Join the Harvard Museums of Science & Culture's ongoing series to learn more.

China's updated regulations on gene editing in humans may not be enough to prevent regulatory negligence and ethical concerns, warns Dr Joy Zhang of Kent University. The regulations set requirements for ethical approval, supervision, and inspection, but experts worry they may not apply to the private sector. Gene editing is a controversial technique that could correct many inherited diseases, but raises the possibility of permanent changes to a person's genetic make-up. The world's leading scientists were stunned when a Chinese scientist claimed to have created the world's first gene-edited babies. This article explores the latest developments in the field of gene editing in China.

A study of rockfish longevity has revealed a set of genes controlling their aging process, leading to the discovery of a previously unappreciated group of genes associated with extended lifespan in humans. The findings show that the same pathways that promote longevity in rockfish also promote longevity in humans. The study identified two major metabolic systems that regulate lifespan in rockfish: the insulin-signaling pathway, which prior research has shown plays a major role in regulating the lifespan of many different animals, and the previously unappreciated flavonoid metabolism pathway. These results provide insights into how to prevent or delay common human diseases of old age.

Do you have a passion for science and a desire to help people? If so, Optometry may be the perfect field of study for you. Optometry is a branch of medicine that focuses on the eyes and vision. It is a fascinating field that combines science, technology, and patient care to help people see clearly and live their best lives. Optometry is all about helping people to see the world around them. As an optometrist, you will use your knowledge of the eyes and vision to diagnose and treat a range of eye conditions, from simple refractive errors to more complex diseases such as glaucoma and cataracts. You will also help people to maintain their eye health and prevent vision problems from developing. One of the most exciting aspects of Optometry is the constant innovation and research that is taking place in the field. From new technologies that allow for more accurate diagnosis and treatment, to groundbreaking research into the causes and treatments of eye diseases, there is always something new and exciting happening in Optometry. At the undergraduate level, typical majors and modules include anatomy and physiology of the eye, optics, visual perception, and ocular disease. Students will also have the opportunity to gain practical experience through clinical placements and internships. After completing their undergraduate degree, students can go on to specialize in areas such as pediatric optometry, contact lenses, or vision therapy. With a degree in Optometry, there are a range of potential job opportunities available. Optometrists can work in private practice, hospitals, clinics, or for government agencies. Some notable employers in the field include Bausch + Lomb, Johnson & Johnson, and Essilor. To succeed in Optometry, students should have a strong background in science, particularly biology and chemistry. They should also possess excellent communication and interpersonal skills, as they will be working closely with patients on a daily basis. If you are passionate about science and helping people, a degree in Optometry may be the perfect choice for you.

Mitochondria are often referred to as the powerhouses of the cell and for good reason. These tiny organelles are responsible for producing the energy that our cells need to function. In this write-up, we'll explore the magic of mitochondria and why they are so important to our health and well-being. Did you know that mitochondria are sometimes referred to as the "second genome"? This is because they have their own DNA and can replicate independently of the cell's nucleus. This discovery, made by Dr. Douglas C. Wallace in the late 1970s, revolutionized our understanding of cellular biology. Another interesting fact about mitochondria is that they are thought to have originated from a symbiotic relationship between early cells and primitive bacteria. Over time, the two organisms evolved together to form the cells that make up our bodies today. This theory, known as the endosymbiotic theory, was first proposed by Dr. Lynn Margulis in the 1960s. So, what exactly do mitochondria do? Well, they are responsible for producing energy in the form of ATP (adenosine triphosphate) through a process called cellular respiration. This energy is then used by our cells to carry out all of their functions, from moving and growing, to repairing and reproducing. It's important to note that our cells can't survive without energy, and without mitochondria, we wouldn't be able to produce enough energy to support our bodies. This is why mitochondria are so critical to our health and well-being. By learning more about the magic of mitochondria, you'll gain a deeper understanding of cellular biology and the role that these tiny organelles play in our lives. So, get reading, reflecting, and exploring!

Singapore's national flower, Papilionanthe Miss Joaquim, has had its entire genetic blueprint decoded, revealing natural products with antioxidant properties and distinctive colors. The study, published in Communications Biology, could lead to future research in gene and metabolite engineering, as well as the discovery of bioactive compounds for healthcare purposes. The collaboration between A\*STAR's Genome Institute of Singapore and SingHealth Duke-NUS Institute of Biodiversity Medicine showcases the power of genetic sequencing technology in preserving and studying Singapore's plant biodiversity.

Have you ever wondered why a black eye turns blue, then green, then yellow, and finally brown before disappearing? It's all because of your hemoglobin, the compound in red blood cells that brings oxygen to your body. When you get hit, the blow crushes tiny blood vessels called capillaries, and red blood cells ooze out of the broken capillaries into the surrounding tissue. From the outside of your skin, this mass of cells looks bluish-black, which is where we get the term, "black and blue". Learning about hemoglobin and how it works in your body can be fascinating and practical knowledge that can help you understand how your body works. It's an example of how exploring academic topics through reading, reflection, and writing can inspire you to learn more about the world around you.

Chemotherapy is a type of cancer treatment that uses drugs to kill rapidly dividing cancer cells in the body. The drugs are delivered through pills and injections and are toxic to all cells in the body, including healthy ones. However, cancer cells are more susceptible to the effects of chemotherapy because they multiply rapidly. Chemotherapy drugs can damage hair follicles, cells of the mouth, gastrointestinal lining, reproductive system, and bone marrow, which can cause side effects such as hair loss, fatigue, infertility, nausea, and vomiting. Despite these side effects, chemotherapy has greatly improved the outlook for many cancer patients. Advances in treatment have led to up to 95% survival rates for testicular cancer and 60% remission rates for acute myeloid leukemia. Researchers are still developing more precise interventions to target cancer cells while minimizing harm to healthy tissues. Learning about chemotherapy can help high school students understand the science behind cancer treatment and the importance of ongoing research to improve outcomes for patients.

We all know how important it is to stay healthy and avoid getting sick. But have you ever wondered about the science behind vaccines? In this video clip, we learn about the key academic concept of how the immune system works to fight off infections and how scientists are working to develop a universal flu vaccine that could protect us against every strain of the flu, even ones that don't exist yet. Learning about this exciting field of research not only expands our knowledge of how vaccines work, but also helps us understand the importance of public health initiatives.

New research has identified gold-based compounds that could treat multidrug-resistant "superbugs", with some effectiveness against several bacteria. Antibiotic resistance is a global public health threat, and the development of new antibiotics has stalled. Gold metalloantibiotics, compounds with a gold ion at their core, could be a promising new approach. Dr. Sara M. Soto Gonzalez and colleagues studied the activity of 19 gold complexes against a range of multidrug-resistant bacteria isolated from patients. The gold compounds were effective against at least one bacterial species studied, with some displaying potent activity against several multidrug-resistant bacteria.

Are you curious about the secrets hidden in ancient DNA? Harvard University has made a groundbreaking discovery that could change the way we understand life on earth. Scientists have managed to reconstruct the genomes of microorganisms up to 100,000 years old, and even revived molecules from the Stone Age in the lab. The group’s findings and genome-reconstruction techniques are outlined in a paper published in Science. This is an exciting breakthrough that could lead to the discovery of new oral species and biochemicals with therapeutic potential. Don't miss out on this fascinating article!

The world is still facing daily COVID-19 infections and the threat of virus mutation, but it's not too late to change the game. A pandemic vaccine alliance, similar to NATO, could be the solution to overcome the "free-rider problem" in global health efforts and ensure the world's biological security.

Weight loss surgery decreases bile acids linked to higher appetite, but lifestyle changes could mimic the effect. Researchers from King's, the University of Nottingham, and Amsterdam University Medical Centre found that gut microbes play a key role in regulating bile acids and metabolism. The study's results have important implications for targeted interventions for metabolic disorders focused on the gut microbiome. Co-author Professor Tim Spector, the co-founder of personalised nutrition company ZOE, highlights the promise of gut microbiome testing in supporting metabolic health.

Severe stress triggers biological age to increase, but it can be reversed. Surgery, pregnancy, and COVID-19 are studied in humans and mice. Researchers found that biological age increased in situations of severe physiological stress but was restored when the stressful situation resolved. This study challenges the concept that biological age can only increase over a person’s lifetime and suggests that it may be possible to identify interventions that could slow or even partially reverse biological age.

An interdisciplinary UCLA research team has developed a tiny implantable device called SymphNode, which has been shown to be able to drive tumours into remission, eliminate metastasis, and prevent the growth of new tumours, resulting in longer survival in mice. This groundbreaking technology may decrease the risk of cancer returning, making it a potential addition to chemotherapy or other first-step treatments for a variety of cancers.

The world of science is constantly evolving, and with it comes new discoveries that can benefit humanity. However, there are also risks associated with scientific research, particularly in the field of biotechnology. Gain of function work involves manipulating the DNA of microorganisms to give them new abilities, which can be used in vaccine production and cancer treatments. However, this work also includes engineering superbugs that could cause a global pandemic if they escape from the lab. While virologists argue that this research could help us prepare for future pandemics, critics believe that the risks outweigh the benefits. To minimize the risk of lab leaks, experts suggest creating international databases of leaks, near-misses, and fixes, as well as developing a robust pandemic early warning system. As students, it is important to understand the benefits and risks of scientific research and to be aware of the measures being taken to minimize the risks associated with it.