Get ready to revolutionize the way we treat cancer and age-related diseases! A new company, GlioQuell, co-founded by Dr. Kambiz Alavian from the Department of Brain Sciences, is developing a cutting-edge approach to target the powerhouses of cancer cells - the mitochondria. By reducing the efficiency of these structures, GlioQuell aims to turn off the cancer cells' energy supply and treat one of the most aggressive forms of cancer - glioblastoma.

HIV, the virus that causes AIDS, is a master of disguise. It can change its outer coat of proteins frequently, making it hard for the immune system to recognise and destroy it. HIV targets Helper T cells, which act as the air traffic controllers of the immune system, coordinating the efforts of other immune cells. If Helper T cells disappear, the whole immune system would have trouble fighting not just HIV but many other illnesses as well. Boosting the immune system against HIV requires getting the Helper T cells back in control. Learning about the immune system and how it works can help you understand how HIV affects the body and how to boost your immune system against it. By exploring this topic through reading, reflection, writing and self-directed projects, you can gain a deeper understanding of the immune system and how to protect yourself from harmful intruders like viruses and bacteria.

As we grow older, our bodies undergo many changes, including changes in our metabolism. Metabolism refers to the chemical processes that occur in our bodies to maintain life. These processes are essential for providing energy, building and repairing tissues, and eliminating waste products. As we age, our metabolic pathways can become altered, leading to various age-related diseases and conditions. One example of a metabolic pathway that is affected by aging is the mitochondrial electron transport chain (ETC). The ETC is responsible for producing ATP, the primary source of energy for our cells. As we age, the function of the ETC can become impaired, leading to a decrease in ATP production and an increase in oxidative stress. This can contribute to age-related diseases such as Alzheimer's disease, Parkinson's disease, and diabetes. Another example is the mTOR (mechanistic target of rapamycin) pathway, which regulates cellular growth and metabolism. Studies have shown that inhibiting the mTOR pathway can increase lifespan in various model organisms, including mice. This has led to increased interest in developing drugs that target this pathway as a potential anti-aging strategy. One of the leading academics in this field is Dr. David Sinclair, a Professor of Genetics at Harvard Medical School. Dr. Sinclair's research has focused on the role of metabolism in aging and age-related diseases, and he has made significant contributions to the field. For example, his research has shown that supplementing with NAD+, a molecule involved in energy metabolism, can improve various aspects of aging in mice. Another leading academic in this field is Dr. Valter Longo, a Professor of Gerontology and Biological Science at the University of Southern California. Dr. Longo's research has focused on the role of fasting and caloric restriction in aging and age-related diseases. His work has shown that periodic fasting can have a range of health benefits, including improving insulin sensitivity and reducing inflammation. In conclusion, the study of metabolic pathways in aging is a fascinating and rapidly growing field. By understanding the complex interplay between metabolism and aging, we can better understand the underlying causes of age-related diseases and conditions. Students who are interested in this topic can continue to explore it through reading and research, or by pursuing their own experiments and projects. With the right tools and resources, they can make meaningful contributions to this exciting field and help improve our understanding of aging and metabolic pathways.

UCLA scientists have identified how immune cells detect and respond to cancer cells, leading to better personalized immunotherapies for patients who do not respond to treatment. Checkpoint inhibitors improve T cells' ability to recognize and attack cancer cells, and the study showed that when immunotherapy is effective, it directs a diverse repertoire of T cells against a small group of selected mutations in a tumor. The researchers adapted advanced gene-editing technology to make unprecedented observations about immune responses in patients with metastatic melanoma receiving anti-PD-1 "checkpoint inhibitor" immunotherapy.

Scientists have developed a groundbreaking treatment for blood cancer using off-the-shelf T-cells. The CALM clinical trial evaluated the potential of UCART19, an "off-the-shelf" CAR-T cell product, against adult patients with B-ALL. The results were recently published in The Lancet Haematology and Cancer Research Communications, showing that 48% of treated patients achieved complete remission lasting an average of 7.4 months. This new approach offers a more efficient and effective alternative to traditional CAR-T cell therapy, providing hope for patients with relapsed or treatment-resistant blood cancers.

A groundbreaking study by the University of Oxford as part of the UK's 100,000 Genomes Project has defined five new subgroups of chronic lymphocytic leukaemia (CLL) and linked these to clinical outcomes, paving the way for more personalized patient care. This is the first study to analyze all the relevant changes in DNA across the entire cancer genome!

Medical research is a fascinating field of study that explores the complexities of the human body and its many diseases. It's an exciting area of research that is constantly evolving, with new discoveries and innovations being made every day. One of the most appealing aspects of medical research is the potential to make a real difference in people's lives. Researchers in this field are at the forefront of developing new treatments and therapies for a wide range of illnesses, from cancer to Alzheimer's disease. One example of groundbreaking research in this field is the development of immunotherapy, a treatment that harnesses the power of the immune system to fight cancer. This innovative approach has already helped to save countless lives and is just one example of the many exciting breakthroughs being made in medical research. At the undergraduate level, students can expect to take a variety of modules that cover topics such as genetics, molecular biology, and epidemiology. These modules provide a solid foundation in the basic principles of medical research and prepare students for further specialisation in areas such as cancer research or infectious diseases. Potential future jobs and roles in medical research include positions as research scientists, clinical trial coordinators, and medical writers. There are also many opportunities to work in public health or in the pharmaceutical industry, with notable employers including the National Institutes of Health, Pfizer, and GlaxoSmithKline. To succeed in this field of study, students should have a strong interest in science and a passion for helping others. They should also possess excellent analytical and critical thinking skills, as well as the ability to work independently and as part of a team. Overall, the study of medical research is an exciting and rewarding field that offers endless possibilities for those who are passionate about making a difference in the world of healthcare.

Childhood cancer is a devastating disease that affects thousands of children every year. However, as cancer is more likely to occur in adults rather than children, research on childhood cancer is often underfunded, leading to fewer treatment options and lower survival rates. One of the biggest challenges in treating childhood cancer is the risk of long-term side effects from chemotherapy and radiation. These treatments can cause developmental delays, learning disabilities, and even secondary cancers later in life. As a result, new treatment strategies are being developed to minimize these risks. One of the most promising new approaches is immunotherapy, a type of treatment that harnesses the power of the immune system to attack cancer cells. CAR T-cell therapy, in which T-cells are genetically engineered to recognize and attack cancer cells, has shown particularly promising results in clinical trials. Another challenge in treating childhood cancer is the lack of targeted therapies. Unlike adult cancers, childhood cancers often have no known driver mutations that can be targeted with precision medicine. Researchers are working to identify new drug targets and develop new treatments that can attack cancer cells while sparing healthy cells. Dr. Kimberly Stegmaier, an oncologist and researcher at the Dana-Farber Cancer Institute, is one of the leading experts in childhood cancer research. She and her team are working to identify new drug targets and develop targeted therapies for childhood cancers. They are also studying the genetic and molecular characteristics of childhood cancers to better understand how they develop and how they can be treated. In conclusion, childhood cancer presents unique challenges that require innovative solutions. While underfunded research and the lack of targeted therapies have made progress difficult, recent developments in immunotherapy, such as CAR T-cell therapy, show promising results. As we continue to fight for a cure, let us also remember the children and families affected by this disease and strive to support them in any way we can.

Did you know that adults catch more than 150 colds throughout their lives, and that a single family of viruses causes 30 to 50% of all colds? Understanding the complex relationship between viruses and our immune systems is not only fascinating, but also highly relevant to our daily lives. By reading about pleconaril, rhinovirus, and CRISPR, you'll learn about the science behind vaccines and antiviral drugs, and how they could help us tackle the common cold. But beyond that, exploring this topic will help you appreciate the incredible complexity and resilience of our immune systems, and the importance of maintaining our health. So grab a cup of tea and your favorite notebook, and get ready to dive into the fascinating world of viruses and immune systems!

Did you know that selecting the embryo with the lowest risk for a given disease can cut the risk for that disease by almost half? This is particularly true for disorders such as schizophrenia and Crohn’s disease. However, the selection process may not lead to significant improvements in non-disease traits such as intelligence. Moreover, the use of preimplantation genetic screening (PES) raises concerns about psychological well-being, social values, and ethics. Learn more about the potential benefits and risks of PES, and how it may impact our society and individuality.

Did you know that only about 2% of the human genome actually codes for proteins? That means the remaining 98% is often dismissed as "junk" DNA, but that couldn't be further from the truth. In fact, a significant portion of that non-coding DNA is made up of repetitive sequences, also known as satellite DNA, which play important roles in gene regulation, genome organization, and even human disease. Repetitive DNA makes up about 50% of the human genome, and while it may seem repetitive and boring, it is actually incredibly diverse and dynamic. Different types of repetitive sequences, such as short tandem repeats (STRs) and transposable elements, can vary in copy number, length, and location across different individuals and populations. This contributes to the remarkable genetic diversity that we see in humans and other species. Repetitive DNA has also been linked to a variety of human diseases, including neurological disorders, cancer, and genetic imprinting disorders. For example, Huntington's disease is caused by an expansion of a repetitive sequence in the huntingtin gene, and fragile X syndrome is caused by the expansion of a repetitive sequence in the FMR1 gene. Despite the significance of repetitive DNA, much of it is still poorly understood. However, leading academics in the field are working to change that. For example, Susan Wessler, a plant geneticist at the University of California, Riverside, has made important contributions to our understanding of transposable elements and their impact on genome evolution. Meanwhile, Sarah Tishkoff, a human geneticist at the University of Pennsylvania, has explored the genetic diversity of African populations and the role of repetitive DNA in human adaptation and disease susceptibility. So why should you care about repetitive DNA? Well, for one, it's a fascinating topic that reveals the complexity and beauty of the genome. But more importantly, it has practical implications for fields like medicine and forensics. Short tandem repeats, for example, are commonly used in DNA profiling and can help identify suspects in criminal investigations or establish paternity. Repetitive DNA is also being studied as a potential target for novel therapies in diseases like cancer. Don't be intimidated by the complexity of the genome – there is always more to learn and discover!

Do you have a passion for science and a desire to help people? If so, Optometry may be the perfect field of study for you. Optometry is a branch of medicine that focuses on the eyes and vision. It is a fascinating field that combines science, technology, and patient care to help people see clearly and live their best lives. Optometry is all about helping people to see the world around them. As an optometrist, you will use your knowledge of the eyes and vision to diagnose and treat a range of eye conditions, from simple refractive errors to more complex diseases such as glaucoma and cataracts. You will also help people to maintain their eye health and prevent vision problems from developing. One of the most exciting aspects of Optometry is the constant innovation and research that is taking place in the field. From new technologies that allow for more accurate diagnosis and treatment, to groundbreaking research into the causes and treatments of eye diseases, there is always something new and exciting happening in Optometry. At the undergraduate level, typical majors and modules include anatomy and physiology of the eye, optics, visual perception, and ocular disease. Students will also have the opportunity to gain practical experience through clinical placements and internships. After completing their undergraduate degree, students can go on to specialize in areas such as pediatric optometry, contact lenses, or vision therapy. With a degree in Optometry, there are a range of potential job opportunities available. Optometrists can work in private practice, hospitals, clinics, or for government agencies. Some notable employers in the field include Bausch + Lomb, Johnson & Johnson, and Essilor. To succeed in Optometry, students should have a strong background in science, particularly biology and chemistry. They should also possess excellent communication and interpersonal skills, as they will be working closely with patients on a daily basis. If you are passionate about science and helping people, a degree in Optometry may be the perfect choice for you.

A study of rockfish longevity has revealed a set of genes controlling their aging process, leading to the discovery of a previously unappreciated group of genes associated with extended lifespan in humans. The findings show that the same pathways that promote longevity in rockfish also promote longevity in humans. The study identified two major metabolic systems that regulate lifespan in rockfish: the insulin-signaling pathway, which prior research has shown plays a major role in regulating the lifespan of many different animals, and the previously unappreciated flavonoid metabolism pathway. These results provide insights into how to prevent or delay common human diseases of old age.

Cancer is a mysterious and deadly disease that claims the lives of 1500 Americans every day. But why is it so common, and why does treatment often fail? In "Cancer: The Evolutionary Legacy", leading researcher Mel Greaves offers clear and convincing answers to these questions by looking at cancer through a Darwinian lens. Greaves argues that human development has trapped us in a nature-nurture mismatch, causing cancer to thrive. With compelling examples from history and modern research, this fascinating book sheds light on the evolutionary context of cancer and its implications for prevention and treatment. Recommended for biology students, medical professionals, and anyone interested in the evolutionary origins of disease, "Cancer: The Evolutionary Legacy" offers a fresh perspective on this complex and elusive disease. With its lucid and engaging style, this book is accessible to readers of all backgrounds and provides a comprehensive overview of cancer research and treatment. Additionally, those interested in the history of medicine and public health will find the compelling examples from history, including the epidemic of scrotal skin cancer in 18th-century chimney sweeps, to be particularly interesting.

Are you interested in pursuing a career that enables you to make a difference in people's lives while helping them? The field of surgery may be the ideal fit for you! Surgeons are highly skilled medical professionals responsible for performing operations to cure and treat a wide range of diseases and injuries. Let's delve deeper into what it takes to build a career in surgery. As a surgeon, your primary responsibility is to perform surgeries and other medical procedures to diagnose and treat various ailments and conditions. You'll be working with patients of all ages, from infants to the elderly, in several specializations, including neurosurgery, orthopedic surgery, plastic surgery, cardiothoracic surgery, and more. One of the most compelling aspects of a career in surgery is the chance to have a significant and long-lasting impact on people's lives. For example, as a neurosurgeon, you can perform life-saving brain surgeries, while as a plastic surgeon, you can help boost someone's confidence and self-esteem by fixing their physical defects. To become a surgeon, you'll need to earn a medical degree, complete a residency program, and get a state license. The entire process of education and training may take up to 14 years, including undergraduate studies in biology, chemistry, or pre-med. Excellent manual dexterity, communication and interpersonal skills, and the ability to work under pressure are essential qualities for success in this field. Attention to detail, critical thinking, and problem-solving skills are equally vital. The job prospects and long-term outlook for surgeons are favorable, with an expected job growth of 4% over the next decade. Surgeons are in high demand worldwide, with hospitals, private clinics, research institutions, and government agencies being some of the potential employers. Numerous top-notch organizations are looking for talented surgeons to join their teams, including the Mayo Clinic, Johns Hopkins Hospital, Cleveland Clinic in the USA, the Royal London Hospital in the UK, and St. Vincent's Hospital in Australia. In conclusion, if you're looking for a fulfilling and exciting career that allows you to make a difference in people's lives while working in a challenging and rewarding field, surgery may be the perfect career path for you. Take the time to explore this field further and see if it's the right choice for you!

Discover the secrets of personalized medicine and revolutionize your approach to health with Dr. Francis Collins' groundbreaking work, The Language of Life. As the head of the Human Genome Project and a recipient of the Presidential Medal of Freedom, Collins offers practical advice on how to utilize the latest medical, scientific, and genetic discoveries for your family's well-being. With accessible and insightful prose, this book is a must-read for anyone interested in the future of healthcare. Join the medical and scientific revolution and unlock the secrets of personalized medicine today! Recommended for healthcare professionals, students of medicine and biology, and anyone interested in the future of healthcare, The Language of Life by Dr. Francis Collins is a must-read. This groundbreaking work describes the latest medical, scientific, and genetic discoveries that are revolutionizing the field of personalized medicine. Collins offers practical advice on how to utilize these discoveries for the betterment of your own and your family's health and well-being. With accessible and insightful prose, this book is sure to inspire and inform readers from a range of fields and interests. Join the revolution and discover the secrets of personalized medicine today!

DNA is a molecule that holds the secrets of life within its code, and it's waiting for you to explore it! This amazing molecule determines our traits, from our physical appearance to our personalities, and it can also tell us about our ancestry, our risk of diseases, and much more. Leading academics in the field of genetics, such as James Watson and Francis Crick, made major contributions to our understanding of DNA by discovering its structure and how it stores and transfers genetic information. Watson and Crick's discovery of the double helix structure of DNA was a major turning point in the field of genetics and opened up new avenues for scientific research. In the early 1990s, the Human Genome Project was launched to map all of the genes in human DNA. This project was a huge success and has had a profound impact on the field of genetics. It allowed scientists to identify specific genes that are associated with different diseases, such as cancer, and has paved the way for new treatments and cures. One of the most fascinating things about DNA is that every person's DNA is 99.9% identical to every other person's DNA. It's the remaining 0.1% that makes each of us unique! Our DNA also contains fascinating stories about our ancestors and their migrations. For example, DNA testing can tell us where our ancestors came from and how they migrated across the world. This is known as genetic genealogy, and it's an exciting field that combines genetics and history. Another fascinating aspect of DNA is its role in evolution. Charles Darwin's theory of evolution by natural selection states that species change over time through the process of natural selection. This process occurs because certain traits that provide an advantage in survival and reproduction become more common in a population over time. DNA mutations can lead to changes in traits, and over many generations, these changes can accumulate and result in new species. By exploring the world of DNA, you will not only deepen your understanding of genetics and biology, but also gain a new appreciation for the complexities and wonders of life. So go ahead, unlock the secrets of life with the power of DNA!

Organ transplants are a life-saving medical breakthrough that have revolutionized the field of medicine. Kidneys are essential organs that filter waste material from the blood and process it into urine. A typical dialysis patient has a poorer life expectancy than many cancers. Removing one kidney should not affect someone's lifespan or quality of life. A kidney from a living donor in general will have a much better quality because it comes from a healthy and tested person. Kidneys are expected to survive up to twice as long on average in the recipient. Currently, it's not allowed to donate a kidney under any form of payment. However, incentivizing people to donate more is actually a way to starve black markets. It's not to recreate them, it's to undermine them. If you reward a person amply for the sacrifice they've made, something they go into with their eyes open and well informed, that's not exploitation. Organ donation is an incredible gift that can save someone's life so palpably, and everyone should consider donating.

Are you tired of feeling helpless and uninformed about your functional bowel disease? Dr. Michael Gershon's groundbreaking book, The Second Brain, offers a new understanding of nervous disorders of the stomach and intestine. With persuasive and impassioned writing, Dr. Gershon fills the gap between what you need to know and what your doctor has time to tell you. This hopeful news is a must-read for anyone suffering from functional bowel disease, as it sheds light on the complex nervous system in our gut and how it affects our overall health. Download your copy today and take control of your health!" Recommended for those in the medical field, individuals with functional bowel disease, and anyone interested in the connection between the gut and overall health, The Second Brain offers a groundbreaking understanding of the nervous system in our gut. Dr. Michael Gershon's passionate writing fills the gap between what patients need to know and what doctors have time to tell them. This book sheds light on the complexity of the gut-brain connection and how it affects our overall well-being. Whether you are a medical professional, a patient, or simply interested in the topic, this book is a must-read for anyone seeking to take control of their health.

Are you fascinated by the human body and its inner workings? Do you have a passion for helping others and making a meaningful impact on people's lives? Then a career in Medicine might be just what you're looking for! Medicine is a field of study that encompasses everything from the smallest cells to the largest organ systems, with a focus on understanding and treating diseases and injuries. It's a challenging and rewarding career that requires a lot of hard work and dedication, but the potential rewards are enormous. Some of the most exciting developments in Medicine today are in the areas of genomics, personalized medicine, and regenerative medicine. Researchers are exploring new ways to use genetics to diagnose and treat diseases, while also developing new treatments that can regenerate damaged tissues and organs. One of the many inspiring figures in Medicine is Dr. Paul Farmer, who has dedicated his life to providing healthcare to some of the world's poorest communities. He founded Partners in Health, an organization that has helped to bring lifesaving medical care to millions of people around the world. At the undergraduate level, students typically study a range of subjects including anatomy, physiology, pharmacology, and pathology. They also gain practical experience through clinical rotations and internships. Some students may choose to specialize in areas such as surgery, pediatrics, or oncology. There are many potential career paths for those who study Medicine, including roles as physicians, surgeons, researchers, and healthcare administrators. Some of the most notable employers in this field include the World Health Organization, Doctors Without Borders, and the Mayo Clinic. To succeed in Medicine, it's important to have a strong foundation in science and math, as well as excellent communication and problem-solving skills. A genuine passion for helping others and a commitment to lifelong learning are also essential. If you're ready to embark on an exciting and rewarding career in Medicine, there's no better time to start exploring your options!